Many important biological processes involve recognition and binding of biomolecules.  An example is the lock-and-key binding of antigens and antibodies.  Applying the principles of molecular recognition and materials design to develop synthetic recognition platforms can overcome many of the limitations associated with natural systems, and allow the development of a new generation of robust and low cost platforms for a broad range of applications.  We are using imprinted hydrogels to study molecular recognition of proteins and enzymes relevant to the development of biosensors, diagnostics, and the development of prevention and treatment of disease.