Endothelial cells form the endothelium that lines the interior of blood vessels.  Through transduction of chemical, physical and mechanical signals, the endothelium controls blood flow and regulates a wide range of processes, including transport between the vascular system and other tissues.  We are using microfluidic platforms, microfabrication tools, soft-lithography, and transwell assays to study how physical and chemical parameters influence the properties of the endothelium.   We are particularly interested in the structure and function of the blood brain barrier, and uncovering the physical and chemical processes that guide the spread of cancer.