Hai-Quan Mao

Associate Professor, Materials Science and Engineering

Hai-Quan Mao at Materials Science and Engineering

office (410) 516-8792

Research Group

Institute for NanoBioTechnology

Maryland Hall 113

Research Interests

  • Biofunctional scaffolds
  • Non-viral gene delivery & drug delivery
  • Stem cell expansion and differentiation
  • Biodegradable polymers

81Publications by Hai-Quan Mao

View on ResearcherID

  • Aligned macroscopic domains of optoelectronic nanostructures prepared via shear-flow assembly of pep

    Wall, B. D.; Diegelmann, S. R.; Zhang, S.; Dawidczyk, T. J.; Wilson, W. L.; Katz, H. E.; Mao, H. Q.; Tovar, J. D.; Adv Mater, 23 5009 (2011)

  • Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging.

    Patil, R. R.; Yu, J.; Banerjee, S. R.; Ren, Y.; Leong, D.; Jiang, X.; Pomper, M.; Tsui, B.; Kraitchman, D. L.; Mao, H. Q.; Mol Ther, 19 1626 (2011)

  • Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA mic

    Nakanishi, M.; Patil, R.; Ren, Y.; Shyam, R.; Wong, P.; Mao, H. Q.; Pharm Res, 28 1723 (2011)

  • Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural

    Mahairaki, V.; Lim, S. H.; Christopherson, G. T.; Xu, L.; Nasonkin, I.; Yu, C.; Mao, H. Q.; Koliatsos, V. E.; Tissue Eng Part A, 17 855 (2011)

  • Signaling cue presentation and cell delivery to promote nerve regeneration.

    Krick, K.; Tammia, M.; Martin, R.; Höke, A.; Mao, H. Q.; Curr Opin Biotechnol, 22 741 (2011)

  • String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their tra

    Jiang, X.; Leong, D.; Ren, Y.; Li, Z.; Torbenson, M. S.; Mao, H. Q.; Pharm Res, 28 1317 (2011)

  • Transient depletion of kupffer cells leads to enhanced transgene expression in rat liver following r

    Dai, H.; Jiang, X.; Leong, K. W.; Mao, H. Q.; Hum Gene Ther, 22 873 (2011)

  • Charge density and molecular weight of polyphosphoramidate gene carrier are key parameters influenci

    Ren, Y.; Jiang, X.; Pan, D.; Mao, H. Q.; Biomacromolecules, 11 3432 (2010)

  • Nanofiber matrix as artificial stem cell niche

    Mao, H.Q.,; Lim, S.H.,; Zhang, S.,; Christopherson, G.T.,; Kam, K.,; Fischer, S.; Biomaterials As Stem Cell Niche, (2010)

  • The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cel

    Lim, S. H.; Liu, X. Y.; Song, H.; Yarema, K. J.; Mao, H. Q.; Biomaterials, 31 9031 (2010)

  • Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene-delivery efficiency.

    Jiang, X.; Zheng, Y.; Chen, H. H.; Leong, K. W.; Wang, T. H.; Mao, H. Q.; Adv Mater, 22 2556 (2010)

  • Electrospun scaffolds for stem cell engineering.

    Lim, SH; Mao, HQ; Adv Drug Deliv Rev, 61 1084 (2009)

  • Current applications and future perspectives of artificial nerve conduits.

    Jiang, X; Lim, SH; Mao, HQ; Chew, SY; Exp Neurol, (2009)

  • Biofunctional coatings via targeted covalent cross-linking of associating triblock proteins.

    Fischer, SE; Mi, L; Mao, HQ; Harden, JL; Biomacromolecules, 10 2408 (2009)

  • Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct

    Das, H; George, JC; Joseph, M; Das, M; Abdulhameed, N; Blitz, A; Khan, M; Sakthivel, R; Mao, HQ; Hoit, BD; Kuppusamy, P; Pompili, VJ; PLoS One, 4 e7325 (2009)

  • Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cel

    Das, H; Abdulhameed, N; Joseph, M; Sakthivel, R; Mao, HQ; Pompili, VJ; Cell Transplant, 18 305 (2009)

  • The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and pr

    Christopherson, GT; Song, H; Mao, HQ; Biomaterials, 30 556 (2009)

  • Simultaneous Non-invasive Analysis of DNA Condensation and Stability by Two-step QD-FRET.

    Chen, HH; Ho, YP; Jiang, X; Mao, HQ; Wang, TH; Leong, KW; Nano Today, 4 125 (2009)

  • Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for

    SUN,TM; JZ,DU; YAN,LF; MAO,HQ; WANG,J; Biomaterials, 29 4348 (2008)

  • Quantitative comparision of intracellular unpacking kinetics of polyplexes by a model constructed fr

    CHEN,HH; YP,HO; JIANG,X; MAO,HQ; WANG,TH; LEONG,KW; Molecular Therapy, 16 324 (2008)

  • Artificial blood brain barrier platform.

    SEARSON,PC; WIRTZ,D; MAO,HQ.; U.S. Provisional Patent Application (JHTT D10176, 9/4/2007), (2007)

  • Multilayered hydrogel microfibers for cell and drug encapsulation

    MAO,HQ; BAKHRU,SH; TREHAN,K; YU,CK.; U.S. Provisional Patent Application (JHTT D10052, 4/19/2007), (2007)

  • Reducing electrospun nanofiber diameter and variability using cationic amphiphiles.

    LIN,K; CHUA,KN; CHRISTOPHERSON,GT; LIM,S; MAO,HQ; Polymer, 48 6384 (2007)

  • PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion.

    JIANG,X; DAI,H; CY,KE; MO,X; TORBENSON,MS; LI,Z; MAO,HQ.; Journal of Controlled Release, 122 297 (2007)

  • Hybrid braided 3-D scaffold for bioartificial liver assist devices.

    HOQUE,ME; MAO,HQ; RAMAKRISHNA,S; Journal of Biomaterials Science-Polymer Edition., 18 45 (2007)

  • Controlling cell adhesion to surfaces via associating bioactive triblock proteins.

    FISCHER,SE; LIU,X; MAO,HQ; HARDEN,JL; Biomaterials, 28 3325 (2007)

  • Dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes

    CHUA,KN; TANG,YN; QUEK,CH; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Acta Biomaterialia, 3 643 (2007)

  • Functional Nanofiber Scaffolds with Different Spacers Modulate Adhesion and Expansion of Cryopreserv

    CHUA,KN; CHAI,C; LEE,PC; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Experimental Hematology, 35 771 (2007)

  • Polyphosphoester micelles for drug and gene delivery

    MAO,HQ; JIANG,X; LEONG,KW; US Provisional Patent, (2006)

  • Controlled microencapsulation of mammalian cells

    MAO,HQ; BAKHRU,BAKHRU; US Provisional Patent, (2006)

  • Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusion

    JIANG,X.; DAI,H.; LEONG,K.W.; GOH,S.H.; MAO,H.Q.; YANG,Y.Y.; Journal of Gene Medicine, 8 477 (2006)

  • Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbi

    JIANG,X.S.; CHAI,C.; ZHANG,Y.; ZHUO,R.X.; MAO,H.Q.; LEONG,K.W.; Biomaterials, 27 2723 (2006)

  • Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds wit

    FENG,Q.; CHAI,C.; JIANG,X.S.; LEONG,K.W.; MAO,H.Q.; Journal of Biomedical Materials Research, Part A, 78 781 (2006)

  • Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery

    DAI,H.; JIANG,X.; TAN,G.C.Y.; CHEN,Y.; TORBENSON,M.; LEONG,K.W.; MAO,H.Q.; International Journal of Nanomedicine., (2006)

  • Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood

    CHUA,K.N.; CHAI,C.; LEE,P.C.; TANG,Y.N.; RAMAKRISHNA,S.; LEONG,K.W.; MAO,H.Q.; Biomaterials, 27 6043 (2006)

  • Characterization of UV-induced graft polymerization of poly(acrylic acid) using optical waveguide sp

    CHU,L.Q.; TAN,W.J.; MAO,H.Q.; KNOLL,W.; Macromolecules, 39 8742 (2006)

  • In situ characterization of moisture sorption/desorption in thin polymer films using optical wavegui

    CHU,L.Q.; MAO,H.Q.; KNOLL,W.; Polymer, 47 7406 (2006)

  • Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficien

    ZHANG,XQ; WANG,XL; ZHANG,PC; LIU,Z; ZHUO,RX; MAO,HQ; LEONG,KW; Journal of Controlled Release, 102 749 (2005)

  • In vitro gene delivery using PAMAM dendrimers with trimesyl core

    ZHANG,XQ; WANG,XL; HUANG,SW; ZHUO,RX; LIU,Z; MAO,HQ; LEONG,KW; Biomacromolecules, 6 341 (2005)

  • Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups

    ZHANG,PC; WANG,J; LEONG,KW; MAO,HQ; Biomacromolecules, 6 54 (2005)

  • Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface

    TAN,WJ; TEO,GP; LIAO,K; LEONG,KW; MAO,HQ; CHAN,V; Biomaterials, 26 891 (2005)

  • Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the ex

    NG,S; YN,WU; ZHOU,Y; TOH,YE; ZZ,HO; CHIA,SM; ZHU,JH; MAO,HQ; YU,H; Biomaterials, 26 3153 (2005)

  • Method of immobilization of clusters of ligands on polymer surface and use in cell engineering

    MAO,HQ; YIN,C; ZHUO,RX; LEONG,KW; U.S. Patent Application, (2005)

  • Biodegradable poly(terephthalate-co-phosphate)s: Synthesis, characterization and drug release proper

    MAO,HQ; SHIPANOVA,I; ZHAO,Z; DANG,W; BROWN,A; LEONG,KW.; Journal of Biomaterials Science-Polymer Edition, 16 135 (2005)

  • Design of poly(phosphoester) nanoparticles for nonviral gene therapy

    MAO,HQ; LEONG,KW; Advances in Genetics, 53 275 (2005)

  • Galactosylated PVDF hollow fiber bioreactor for hepatocyte culture

    LU,HF; LIM,WS; ZHANG,PC; CHIA,SM; YU,H; MAO,HQ; LEONG,KW; Tissue Engineering, 11 1667 (2005)

  • Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte

    LU,HF; CHUA,KN; ZHANG,PC; LIM,WS; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Acta Biomaterialia, 1 399 (2005)

  • Controlled delivery of therapeutic agents by insertable medical devices

    LI,WP; MAO,HQ; LEONG,KW.; U.S. Patent 6,899,731, (2005)

  • Biologically useful polyphosphates

    LEONG,KW; WEN,J; MAO,HQ; U.S. Patent 6,852,709, (2005)

  • pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylen

    FANG,N; TAN,WJ; LEONG,KW; MAO,HQ; CHAN,V.; Colloids Surf B Biointerfaces, 42 245 (2005)

  • Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold

    CHUA,KN; LIM,WS; ZHANG,P; LU,H; WEN,J; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Biomaterials, 26 2537 (2005)

  • Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells

    CHIA,SM; LIN,PC; QUEK,CH; YIN,C; MAO,HQ; LEONG,KW; XU,X; GOH,CH; ML,NG; YU,H; Journal of Biotechnology, 118 434 (2005)

  • Biodegradable polyphosphoester micelles for gene delivery

    WEN,J.; MAO,H.Q.; LI,W.; LIN,K.Y.; LEONG,K.W.; Journal of Pharmaceutical Sciences., 93 2142 (2004)

  • Evaluation of collagen and methylated collagen as gene carriers

    WANG,J.; LEE,I.L.; LIM,W.S.; CHIA,S.M.; YU,H.; LEONG,K.W.; MAO,H.Q.; International Journal of Pharmaceutics., 279 115 (2004)

  • Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency

    WANG,J.; GAO,S.J.; ZHANG,P.C.; WANG,S.; MAO,H.Q.; LEONG,K.W.; Gene Therapy, (2004)

  • Poly(phosphoester) ionomers as tissue-engineering scaffolds

    WAN,A.C.; MAO,H.Q.; WANG,S.; PHUA,S.H.; LEE,G.P.; PAN,J.; LU,S.; WANG,J.; LEONG,K.W.; Journal of Biomedical Materials Research, 70B 91 (2004)

  • Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat

    QUEK,C.H.; LI,J.; SUN,T.; CHAN,M.L.H.; MAO,H.Q.; GAN,L.M.; LEONG,K.W.; YU,H.; Biomaterials, 25 3531 (2004)

  • Polymeric scaffolds for tissue engineering

    MAO,H.Q.; LEONG,K.W.; HUANG,N.; WOO,S.; Frontiers in Biomedical Engineering, (2004)

  • CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable

    LI,Y.; WANG,J.; LEE,C.G.; WANG,C.Y.; GAO,S.J.; TANG,G.P.; MA,Y.X.; YU,H.; MAO,H.Q.; LEONG,K.W.; WANG,S.; Gene Therapy, 11 109 (2004)

  • Phosphate based biodegradable polymers

    LEONG,K.W.; WEN,J.; ZHUO,R.X.; MAO,H.Q.; U.S. Patent, (2004)

  • Water-soluble and nonionic polyphosphoester: synthesis, degradation, biocompatibility and enhancemen

    HUANG,S.W.; WANG,J.; ZHANG,P.C.; MAO,H.Q.; ZHUO,R.X.; LEONG,K.W.; Biomacromolecules, 5 306 (2004)

  • Polyphosphoesters in drug and gene delivery

    ZHAO,Z.; WANG,J.; MAO,H.Q.; LEONG,K.W.; Advanced Drug Delivery Reviews, 55 483 (2003)

  • Immobilization of galactose ligands on acrylic acid graft-copolymerized poly(ethylene terephthalate)

    YING,L.; YIN,C.; ZHUO,R.X.; LEONG,K.W.; MAO,H.Q.; KANG,E.T.; NEOH,K.G.; Biomacromolecules, 4 157 (2003)

  • High density of immobilized galactose ligand enhances hepatocyte attachment and function

    YIN,C.; YING,L.; ZHANG,P.C.; ZHUO,R.X.; KANG,E.T.; LEONG,K.W.; MAO.,H.Q.; Journal of Biomedical Materials Research, 67A 1093 (2003)

  • Adhesion contact dynamics of HepG2 cells on galactose immobilized substrates

    YIN,C.; LIAO,K.; MAO,H.Q.; LEONG,K.W.; ZHUO,R.X.; CHAN,V.; Biomaterials, 24 139 (2003)

  • Microcapsules with improved mechanical stability for hepatocyte culture

    YIN,C.; CHIA,S.M.; QUEK,C.H.; YU,H.; ZHUO,R.X.; LEONG,K.W.; MAO,H.Q.; Biomaterials, 24 1771 (2003)

  • Microcapsules with improved mechanical stability for hepatocyte culture.

    Yin, C.; Mien Chia, S.; Hoon Quek, C.; Yu, H.; Zhuo, R. X.; Leong, K. W.; Mao, H. Q.; Biomaterials, 24 1771 (2003)

  • Adhesion contact dynamics of HepG2 cells on galactose-immobilized substrates.

    Yin, C.; Liao, K.; Mao, H. Q.; Leong, K. W.; Zhuo, R. X.; Chan, V.; Biomaterials, 24 837 (2003)

  • Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve g

    XU,X.; YEE,W.C.; HWANG,P.Y.K.; YU,H.; WAN,A.C.A.; GAO,S.; BOON,K.L.; MAO,H.Q.; LEONG,K.W.; WANG,S.; Biomaterials. 24(13): 2405-2412 (2003)., 24 2405 (2003)

  • Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoest

    WANG,J.; HUANG,S.W.; ZHANG,P.C.; MAO,H.Q.; LEONG,K.W.; International Journal of Pharmaceuticals, 265 75 (2003)

  • Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance

    LU,H.F.; LIM,W.S.; WANG,J.; TANG,Z.Q.; ZHANG,P.C.; LEONG,K.W.; CHIA,S.M.; YU,H.; MAO,H.Q.; Biomaterials, 24 4893 (2003)

  • Functionalization of poly(ethylene terephthalate) film by pulsed plasma deposition of maleic anhydri

    HU,J.J.; YIN,C.; MAO,H.Q.; TAMADA,K.; KNOLL,W.G.; Advanced Functional Materials, 13 692 (2003)

  • BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer

    FANG,N.; WANG,J.; MAO,H.Q.; LEONG,K.W.; CHAN,V.; Colloids and Surfaces B: Biointerfaces, 29 233 (2003)

  • Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral va

    CHEW,J.L.; WOLFOWICZ,C.B.; MAO,H.Q.; LEONG,K.W.; CHUA,K.Y.; Vaccine, 21 2720 (2003)

  • Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carri

    Wang, J.; Zhang, P. C.; Mao, H. Q.; Leong, K. W.; Gene Ther, 9 1254 (2002)

  • New polyphosphoramidate with a spermidine side chain as a gene carrier.

    Wang, J.; Zhang, P. C.; Lu, H. F.; Ma, N.; Wang, S.; Mao, H. Q.; Leong, K. W.; J Control Release, 83 157 (2002)

  • A novel biodegradable gene carrier based on polyphosphoester.

    Wang, J.; Mao, H. Q.; Leong, K. W.; J Am Chem Soc, 123 9480 (2001)

  • Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency

    Mao, H. Q.; Roy, K.; Troung-Le, V. L.; Janes, K. A.; Lin, K. Y.; Wang, Y.; August, J. T.; Leong, K. W.; J Control Release, 70 399 (2001)

  • Gene transfer by DNA-gelatin nanospheres.

    Truong-Le, V. L.; Walsh, S. M.; Schweibert, E.; Mao, H. Q.; Guggino, W. B.; August, J. T.; Leong, K. W.; Arch Biochem Biophys, 361 47 (1999)

  • Oral gene delivery with chitosan—DNA nanoparticles generates immunologic protection in a murine mod

    Roy, K.; Mao, H. Q.; Huang, S. K.; Leong, K. W.; Nat Med, 5 387 (1999)

  • DNA-polycation nanospheres as non-viral gene delivery vehicles.

    Leong, K. W.; Mao, H. Q.; Truong-Le, V. L.; Roy, K.; Walsh, S. M.; August, J. T.; J Control Release, 53 183 (1998)

Awards

  • National Collegiate Inventors and Innovators Alliance (NCIIA) Advanced E-Team Grant: “A Novel Hydrogel Microfiber for Small Diameter Vascular Grafts” $19,900; Student Team (Leader: Kartik Trehan, Adviser: Dr. Mao), July 01, 2007 - June 30, 2008.
  • National Collegiate Inventors and Innovators Alliance (NCIIA) Advanced E-Team Grant: “Rotavirus Vaccination via Oral Thin Film Delivery”, $16,000; Student Team (Leader: Christopher Yu, Adviser: Dr. Mao), July 01, 2007 - June 30, 2008.
  • NCIIA BME Innovation, Design and Entrepreneurship Award (First Place) Student team: Christopher Yu, Rohan Agrawal, Yang Li, Andrew Liu, Dhanya Rangaraj Adviser: Hai-Quan Mao, July 01, 2007 - June 30, 2008.
  • 2002 Young Investigator Award, National University of Singapore, January 2002, Singapore, 2002 - 2002.
  • Controlled Release Society-Capsugel Award for Outstanding Research in Innovative Aspects of Controlled Drug Release, June 2001, San Diego, CA (Supervising postdoctoral research), 2001 - 2001.
  • Controlled Release Society-Capsugel Award for Outstanding Research in Innovative Aspects of Controlled Drug Release, June 1998, Las Vegas, Nevada, 1998 - 1998.
  • Controlled Release Society-Cygnus Graduate Student Award for Outstanding Work in Drug Delivery, June 1997, Stockholm, Sweden, 1997 - 1997

Group Members