Hai-Quan Mao

Associate Professor, Materials Science and Engineering

Hai-Quan Mao at Materials Science and Engineering

office (410) 516-8792

Research Group

Institute for NanoBioTechnology

Maryland Hall 113

Research Interests

  • Biofunctional scaffolds
  • Non-viral gene delivery & drug delivery
  • Stem cell expansion and differentiation
  • Biodegradable polymers

Classes

  • 510.316 - Biomaterials I (Fall 2013) - This course offers an overview of principles and properties of biomedical materials. Topics include properties of materials used in medicine, synthesis and properties of polymeric materials, polymeric biomaterials, natural and recombinant biomaterials, biodegradable materials, hydrogels, stimuli-sensitive materials, and characterizations of biomaterials.

87Publications by Hai-Quan Mao

View on ResearcherID

  • Artificial blood brain barrier platform.

    SEARSON,PC; WIRTZ,D; MAO,HQ.; U.S. Provisional Patent Application (JHTT D10176, 9/4/2007), (2007)

  • Multilayered hydrogel microfibers for cell and drug encapsulation

    MAO,HQ; BAKHRU,SH; TREHAN,K; YU,CK.; U.S. Provisional Patent Application (JHTT D10052, 4/19/2007), (2007)

  • Polyphosphoester micelles for drug and gene delivery

    MAO,HQ; JIANG,X; LEONG,KW; US Provisional Patent, (2006)

  • Controlled microencapsulation of mammalian cells

    MAO,HQ; BAKHRU,BAKHRU; US Provisional Patent, (2006)

  • Method of immobilization of clusters of ligands on polymer surface and use in cell engineering

    MAO,HQ; YIN,C; ZHUO,RX; LEONG,KW; U.S. Patent Application, (2005)

  • Controlled delivery of therapeutic agents by insertable medical devices

    LI,WP; MAO,HQ; LEONG,KW.; U.S. Patent 6,899,731, (2005)

  • Biologically useful polyphosphates

    LEONG,KW; WEN,J; MAO,HQ; U.S. Patent 6,852,709, (2005)

  • Phosphate based biodegradable polymers

    LEONG,K.W.; WEN,J.; ZHUO,R.X.; MAO,H.Q.; U.S. Patent, (2004)

  • Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic Fat

    Tang, Z. H.; Liang, S.; Potter, J.; Jiang, X.; Mao, H. Q.; Li, Z.; J Immunol, 190 ()

  • Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models

    Loo, Y.; Grigsby, C. L.; Yamanaka, Y. J.; Chellappan, M. K.; Jiang, X.; Mao, H. Q.; Leong, K. W.; J Control Release, 160 ()

  • Liver-targeted gene delivery through retrograde intrabiliary infusion

    Jiang, X.; Ren, Y.; Williford, J. M.; Li, Z.; Mao, H. Q.; Methods Mol Biol, 948 ()

  • Plasmid-Templated Shape Control of Condensed DNA-Block Copolymer Nanoparticles

    Jiang, X.; Qu, W.; Pan, D.; Ren, Y.; Williford, J. M.; Cui, H.; Luijten, E.; Mao, H. Q.; Adv Mater, 25 ()

  • Biomimetics of the extracellular matrix: an integrated three-dimensional fiber-hydrogel composite fo

    Coburn, Jeannine; Gibson, Matt; Bandalini, Pierre Alain; Laird, Christopher; Mao, Hai-Quan; Moroni, Lorenzo; Seliktar, Dror; Elisseeff, Jennifer; Smart Structures and Systems, 7 ()

  • Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering ost

    Aggarwal, R.; Lu, J.; Kanji, S.; Joseph, M.; Das, M.; Noble, G. J.; McMichael, B. K.; Agarwal, S.; Hart, R. T.; Sun, Z.; Lee, B. S.; Rosol, T. J.; Jackson, R.; Mao, H. Q.; Pompili, V. J.; Das, H.; PLoS One, 7 ()

  • Polyphosphoesters in drug and gene delivery

    ZHAO,Z.; WANG,J.; MAO,H.Q.; LEONG,K.W.; Advanced Drug Delivery Reviews, 55 ()

  • Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficien

    ZHANG,XQ; WANG,XL; ZHANG,PC; LIU,Z; ZHUO,RX; MAO,HQ; LEONG,KW; Journal of Controlled Release, 102 ()

  • In vitro gene delivery using PAMAM dendrimers with trimesyl core

    ZHANG,XQ; WANG,XL; HUANG,SW; ZHUO,RX; LIU,Z; MAO,HQ; LEONG,KW; Biomacromolecules, 6 ()

  • Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups

    ZHANG,PC; WANG,J; LEONG,KW; MAO,HQ; Biomacromolecules, 6 ()

  • Immobilization of galactose ligands on acrylic acid graft-copolymerized poly(ethylene terephthalate)

    YING,L.; YIN,C.; ZHUO,R.X.; LEONG,K.W.; MAO,H.Q.; KANG,E.T.; NEOH,K.G.; Biomacromolecules, 4 ()

  • High density of immobilized galactose ligand enhances hepatocyte attachment and function

    YIN,C.; YING,L.; ZHANG,P.C.; ZHUO,R.X.; KANG,E.T.; LEONG,K.W.; MAO.,H.Q.; Journal of Biomedical Materials Research, 67A ()

  • Adhesion contact dynamics of HepG2 cells on galactose immobilized substrates

    YIN,C.; LIAO,K.; MAO,H.Q.; LEONG,K.W.; ZHUO,R.X.; CHAN,V.; Biomaterials, 24 ()

  • Microcapsules with improved mechanical stability for hepatocyte culture

    YIN,C.; CHIA,S.M.; QUEK,C.H.; YU,H.; ZHUO,R.X.; LEONG,K.W.; MAO,H.Q.; Biomaterials, 24 ()

  • Microcapsules with improved mechanical stability for hepatocyte culture.

    Yin, C.; Mien Chia, S.; Hoon Quek, C.; Yu, H.; Zhuo, R. X.; Leong, K. W.; Mao, H. Q.; Biomaterials, 24 ()

  • Adhesion contact dynamics of HepG2 cells on galactose-immobilized substrates.

    Yin, C.; Liao, K.; Mao, H. Q.; Leong, K. W.; Zhuo, R. X.; Chan, V.; Biomaterials, 24 ()

  • Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve g

    XU,X.; YEE,W.C.; HWANG,P.Y.K.; YU,H.; WAN,A.C.A.; GAO,S.; BOON,K.L.; MAO,H.Q.; LEONG,K.W.; WANG,S.; Biomaterials. 24(13): 2405-2412 (2003)., 24 ()

  • Biodegradable polyphosphoester micelles for gene delivery

    WEN,J.; MAO,H.Q.; LI,W.; LIN,K.Y.; LEONG,K.W.; Journal of Pharmaceutical Sciences., 93 ()

  • Evaluation of collagen and methylated collagen as gene carriers

    WANG,J.; LEE,I.L.; LIM,W.S.; CHIA,S.M.; YU,H.; LEONG,K.W.; MAO,H.Q.; International Journal of Pharmaceutics., 279 ()

  • Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoest

    WANG,J.; HUANG,S.W.; ZHANG,P.C.; MAO,H.Q.; LEONG,K.W.; International Journal of Pharmaceuticals, 265 ()

  • Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency

    WANG,J.; GAO,S.J.; ZHANG,P.C.; WANG,S.; MAO,H.Q.; LEONG,K.W.; Gene Therapy, ()

  • Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carri

    Wang, J.; Zhang, P. C.; Mao, H. Q.; Leong, K. W.; Gene Ther, 9 ()

  • New polyphosphoramidate with a spermidine side chain as a gene carrier.

    Wang, J.; Zhang, P. C.; Lu, H. F.; Ma, N.; Wang, S.; Mao, H. Q.; Leong, K. W.; J Control Release, 83 ()

  • A novel biodegradable gene carrier based on polyphosphoester.

    Wang, J.; Mao, H. Q.; Leong, K. W.; J Am Chem Soc, 123 ()

  • Poly(phosphoester) ionomers as tissue-engineering scaffolds

    WAN,A.C.; MAO,H.Q.; WANG,S.; PHUA,S.H.; LEE,G.P.; PAN,J.; LU,S.; WANG,J.; LEONG,K.W.; Journal of Biomedical Materials Research, 70B ()

  • Aligned macroscopic domains of optoelectronic nanostructures prepared via shear-flow assembly of pep

    Wall, B. D.; Diegelmann, S. R.; Zhang, S.; Dawidczyk, T. J.; Wilson, W. L.; Katz, H. E.; Mao, H. Q.; Tovar, J. D.; Adv Mater, 23 ()

  • Gene transfer by DNA-gelatin nanospheres.

    Truong-Le, V. L.; Walsh, S. M.; Schweibert, E.; Mao, H. Q.; Guggino, W. B.; August, J. T.; Leong, K. W.; Arch Biochem Biophys, 361 ()

  • Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface

    TAN,WJ; TEO,GP; LIAO,K; LEONG,KW; MAO,HQ; CHAN,V; Biomaterials, 26 ()

  • Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for

    SUN,TM; JZ,DU; YAN,LF; MAO,HQ; WANG,J; Biomaterials, 29 ()

  • Oral gene delivery with chitosan—DNA nanoparticles generates immunologic protection in a murine mod

    Roy, K.; Mao, H. Q.; Huang, S. K.; Leong, K. W.; Nat Med, 5 ()

  • Charge density and molecular weight of polyphosphoramidate gene carrier are key parameters influenci

    Ren, Y.; Jiang, X.; Pan, D.; Mao, H. Q.; Biomacromolecules, 11 ()

  • Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat

    QUEK,C.H.; LI,J.; SUN,T.; CHAN,M.L.H.; MAO,H.Q.; GAN,L.M.; LEONG,K.W.; YU,H.; Biomaterials, 25 ()

  • Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging.

    Patil, R. R.; Yu, J.; Banerjee, S. R.; Ren, Y.; Leong, D.; Jiang, X.; Pomper, M.; Tsui, B.; Kraitchman, D. L.; Mao, H. Q.; Mol Ther, 19 ()

  • Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the ex

    NG,S; YN,WU; ZHOU,Y; TOH,YE; ZZ,HO; CHIA,SM; ZHU,JH; MAO,HQ; YU,H; Biomaterials, 26 ()

  • Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA mic

    Nakanishi, M.; Patil, R.; Ren, Y.; Shyam, R.; Wong, P.; Mao, H. Q.; Pharm Res, 28 ()

  • Biodegradable poly(terephthalate-co-phosphate)s: Synthesis, characterization and drug release proper

    MAO,HQ; SHIPANOVA,I; ZHAO,Z; DANG,W; BROWN,A; LEONG,KW.; Journal of Biomaterials Science-Polymer Edition, 16 ()

  • Design of poly(phosphoester) nanoparticles for nonviral gene therapy

    MAO,HQ; LEONG,KW; Advances in Genetics, 53 ()

  • Polymeric scaffolds for tissue engineering

    MAO,H.Q.; LEONG,K.W.; HUANG,N.; WOO,S.; Frontiers in Biomedical Engineering, ()

  • Nanofiber matrix as artificial stem cell niche

    Mao, H.Q.,; Lim, S.H.,; Zhang, S.,; Christopherson, G.T.,; Kam, K.,; Fischer, S.; Biomaterials As Stem Cell Niche, ()

  • Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency

    Mao, H. Q.; Roy, K.; Troung-Le, V. L.; Janes, K. A.; Lin, K. Y.; Wang, Y.; August, J. T.; Leong, K. W.; J Control Release, 70 ()

  • Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural

    Mahairaki, V.; Lim, S. H.; Christopherson, G. T.; Xu, L.; Nasonkin, I.; Yu, C.; Mao, H. Q.; Koliatsos, V. E.; Tissue Eng Part A, 17 ()

  • Galactosylated PVDF hollow fiber bioreactor for hepatocyte culture

    LU,HF; LIM,WS; ZHANG,PC; CHIA,SM; YU,H; MAO,HQ; LEONG,KW; Tissue Engineering, 11 ()

  • Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte

    LU,HF; CHUA,KN; ZHANG,PC; LIM,WS; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Acta Biomaterialia, 1 ()

  • Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance

    LU,H.F.; LIM,W.S.; WANG,J.; TANG,Z.Q.; ZHANG,P.C.; LEONG,K.W.; CHIA,S.M.; YU,H.; MAO,H.Q.; Biomaterials, 24 ()

  • Reducing electrospun nanofiber diameter and variability using cationic amphiphiles.

    LIN,K; CHUA,KN; CHRISTOPHERSON,GT; LIM,S; MAO,HQ; Polymer, 48 ()

  • Electrospun scaffolds for stem cell engineering.

    Lim, SH; Mao, HQ; Adv Drug Deliv Rev, 61 ()

  • The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cel

    Lim, S. H.; Liu, X. Y.; Song, H.; Yarema, K. J.; Mao, H. Q.; Biomaterials, 31 ()

  • CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable

    LI,Y.; WANG,J.; LEE,C.G.; WANG,C.Y.; GAO,S.J.; TANG,G.P.; MA,Y.X.; YU,H.; MAO,H.Q.; LEONG,K.W.; WANG,S.; Gene Therapy, 11 ()

  • DNA-polycation nanospheres as non-viral gene delivery vehicles.

    Leong, K. W.; Mao, H. Q.; Truong-Le, V. L.; Roy, K.; Walsh, S. M.; August, J. T.; J Control Release, 53 ()

  • Signaling cue presentation and cell delivery to promote nerve regeneration.

    Krick, K.; Tammia, M.; Martin, R.; Höke, A.; Mao, H. Q.; Curr Opin Biotechnol, 22 ()

  • PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion.

    JIANG,X; DAI,H; CY,KE; MO,X; TORBENSON,MS; LI,Z; MAO,HQ.; Journal of Controlled Release, 122 ()

  • Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusion

    JIANG,X.; DAI,H.; LEONG,K.W.; GOH,S.H.; MAO,H.Q.; YANG,Y.Y.; Journal of Gene Medicine, 8 ()

  • Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbi

    JIANG,X.S.; CHAI,C.; ZHANG,Y.; ZHUO,R.X.; MAO,H.Q.; LEONG,K.W.; Biomaterials, 27 ()

  • Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene-delivery efficiency.

    Jiang, X.; Zheng, Y.; Chen, H. H.; Leong, K. W.; Wang, T. H.; Mao, H. Q.; Adv Mater, 22 ()

  • Current applications and future perspectives of artificial nerve conduits.

    Jiang, X; Lim, SH; Mao, HQ; Chew, SY; Exp Neurol, ()

  • String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their tra

    Jiang, X.; Leong, D.; Ren, Y.; Li, Z.; Torbenson, M. S.; Mao, H. Q.; Pharm Res, 28 ()

  • Water-soluble and nonionic polyphosphoester: synthesis, degradation, biocompatibility and enhancemen

    HUANG,S.W.; WANG,J.; ZHANG,P.C.; MAO,H.Q.; ZHUO,R.X.; LEONG,K.W.; Biomacromolecules, 5 ()

  • Functionalization of poly(ethylene terephthalate) film by pulsed plasma deposition of maleic anhydri

    HU,J.J.; YIN,C.; MAO,H.Q.; TAMADA,K.; KNOLL,W.G.; Advanced Functional Materials, 13 ()

  • Hybrid braided 3-D scaffold for bioartificial liver assist devices.

    HOQUE,ME; MAO,HQ; RAMAKRISHNA,S; Journal of Biomaterials Science-Polymer Edition., 18 ()

  • Controlling cell adhesion to surfaces via associating bioactive triblock proteins.

    FISCHER,SE; LIU,X; MAO,HQ; HARDEN,JL; Biomaterials, 28 ()

  • Biofunctional coatings via targeted covalent cross-linking of associating triblock proteins.

    Fischer, SE; Mi, L; Mao, HQ; Harden, JL; Biomacromolecules, 10 ()

  • Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds wit

    FENG,Q.; CHAI,C.; JIANG,X.S.; LEONG,K.W.; MAO,H.Q.; Journal of Biomedical Materials Research, Part A, 78 ()

  • pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylen

    FANG,N; TAN,WJ; LEONG,KW; MAO,HQ; CHAN,V.; Colloids Surf B Biointerfaces, 42 ()

  • BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer

    FANG,N.; WANG,J.; MAO,H.Q.; LEONG,K.W.; CHAN,V.; Colloids and Surfaces B: Biointerfaces, 29 ()

  • Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct

    Das, H; George, JC; Joseph, M; Das, M; Abdulhameed, N; Blitz, A; Khan, M; Sakthivel, R; Mao, HQ; Hoit, BD; Kuppusamy, P; Pompili, VJ; PLoS One, 4 ()

  • Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cel

    Das, H; Abdulhameed, N; Joseph, M; Sakthivel, R; Mao, HQ; Pompili, VJ; Cell Transplant, 18 ()

  • Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery

    DAI,H.; JIANG,X.; TAN,G.C.Y.; CHEN,Y.; TORBENSON,M.; LEONG,K.W.; MAO,H.Q.; International Journal of Nanomedicine., ()

  • Transient depletion of kupffer cells leads to enhanced transgene expression in rat liver following r

    Dai, H.; Jiang, X.; Leong, K. W.; Mao, H. Q.; Hum Gene Ther, 22 ()

  • Dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes

    CHUA,KN; TANG,YN; QUEK,CH; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Acta Biomaterialia, 3 ()

  • Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold

    CHUA,KN; LIM,WS; ZHANG,P; LU,H; WEN,J; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Biomaterials, 26 ()

  • Functional Nanofiber Scaffolds with Different Spacers Modulate Adhesion and Expansion of Cryopreserv

    CHUA,KN; CHAI,C; LEE,PC; RAMAKRISHNA,S; LEONG,KW; MAO,HQ; Experimental Hematology, 35 ()

  • Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood

    CHUA,K.N.; CHAI,C.; LEE,P.C.; TANG,Y.N.; RAMAKRISHNA,S.; LEONG,K.W.; MAO,H.Q.; Biomaterials, 27 ()

  • Characterization of UV-induced graft polymerization of poly(acrylic acid) using optical waveguide sp

    CHU,L.Q.; TAN,W.J.; MAO,H.Q.; KNOLL,W.; Macromolecules, 39 ()

  • In situ characterization of moisture sorption/desorption in thin polymer films using optical wavegui

    CHU,L.Q.; MAO,H.Q.; KNOLL,W.; Polymer, 47 ()

  • The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and pr

    Christopherson, GT; Song, H; Mao, HQ; Biomaterials, 30 ()

  • Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells

    CHIA,SM; LIN,PC; QUEK,CH; YIN,C; MAO,HQ; LEONG,KW; XU,X; GOH,CH; ML,NG; YU,H; Journal of Biotechnology, 118 ()

  • Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral va

    CHEW,J.L.; WOLFOWICZ,C.B.; MAO,H.Q.; LEONG,K.W.; CHUA,K.Y.; Vaccine, 21 ()

  • Quantitative comparision of intracellular unpacking kinetics of polyplexes by a model constructed fr

    CHEN,HH; YP,HO; JIANG,X; MAO,HQ; WANG,TH; LEONG,KW; Molecular Therapy, 16 ()

  • Simultaneous Non-invasive Analysis of DNA Condensation and Stability by Two-step QD-FRET.

    Chen, HH; Ho, YP; Jiang, X; Mao, HQ; Wang, TH; Leong, KW; Nano Today, 4 ()

Awards

  • National Collegiate Inventors and Innovators Alliance (NCIIA) Advanced E-Team Grant: “A Novel Hydrogel Microfiber for Small Diameter Vascular Grafts” $19,900; Student Team (Leader: Kartik Trehan, Adviser: Dr. Mao), July 01, 2007 - June 30, 2008.
  • National Collegiate Inventors and Innovators Alliance (NCIIA) Advanced E-Team Grant: “Rotavirus Vaccination via Oral Thin Film Delivery”, $16,000; Student Team (Leader: Christopher Yu, Adviser: Dr. Mao), July 01, 2007 - June 30, 2008.
  • NCIIA BME Innovation, Design and Entrepreneurship Award (First Place) Student team: Christopher Yu, Rohan Agrawal, Yang Li, Andrew Liu, Dhanya Rangaraj Adviser: Hai-Quan Mao, July 01, 2007 - June 30, 2008.
  • 2002 Young Investigator Award, National University of Singapore, January 2002, Singapore, 2002 - 2002.
  • Controlled Release Society-Capsugel Award for Outstanding Research in Innovative Aspects of Controlled Drug Release, June 2001, San Diego, CA (Supervising postdoctoral research), 2001 - 2001.
  • Controlled Release Society-Capsugel Award for Outstanding Research in Innovative Aspects of Controlled Drug Release, June 1998, Las Vegas, Nevada, 1998 - 1998.
  • Controlled Release Society-Cygnus Graduate Student Award for Outstanding Work in Drug Delivery, June 1997, Stockholm, Sweden, 1997 - 1997

Group Members